|
Trilostane is actually not a new medication in the treatment of Cushing's
disease. We have been using it for four to five years. However, what is new
is the change in dosing schedules. Previously most endocrinologists recommended
a once-daily dosing. At this point, the dosing recommendations is twice daily
with the dose being much smaller. This change reflects further research into
the effectiveness and blood levels of Trilostane using it once or twice daily.
Research has shown repeatedly, that blood levels of Trilostane are higher when
the medication is given twice daily.
Trilostane is a safe and very effective medication for the treatment of
Cushing's Disease (pituitary hyperadrenocorticsm). The drug only inhibits one
of the final steps in making cortisol. There are no untoward effects on the
adrenal glands as were oftentimes seen using the older treatment (mitotane).
If your pet is taking Trilostane, please call the office for instructions on
how to change the dosing of the medication.
|
